Every guy remembers the girl who got away. For Spider-Man, that girl is Mary Jane Watson. For reasons neither of them can quite put their finger on, a relationship that should have been a love for the ages just never worked out. After the break-up, MJ headed west to pursue her acting career, while the wall-crawler stayed in New York to defend the city he loves. They still share fond feeling for each other, but whenever they try to get together something seems to get in the way.
* Character descriptions are from Marvel Universe packaging.